OpenClinica

OpenClinica occupies an incredibly unique, highly disruptive, and fiercely noble position in the market. It originally began as an "Open Source" platform, deeply embedding itself into the global Academic, Non-Profit, and Government research communities who were completely priced out of the massive corporate software market. It has since evolved into a highly robust, commercial cloud platform. Its absolute biggest differentiator is "EHR (Electronic Health Record) eSource." This is the holy grail of clinical trials. Normally, a nurse types patient data into Epic (the hospital software), and then a research coordinator manually re-types that exact same data into the trial EDC (causing massive errors and delays). OpenClinica uses the advanced SMART on FHIR protocol to physically extract the data directly from the hospital's Epic system and inject it directly into the trial database, eliminating manual entry. Because of its open-source DNA, its "Interoperability and Flexibility" are incredible. It does not try to lock you into a massive closed ecosystem. It plays incredibly nicely with other systems. A research team can use OpenClinica for the heavy data capture, connect it via API to a different statistical analysis software, and export raw datasets in highly standardized CDISC formats flawlessly.